Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC005
Sex MALE
Dominant hand LEFT
Test administered by neuromedic@manusdevices.net
Test date and time 2022-11-11 08:28
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment tbl Carboma 4x150mg tbl Oprimea a 0,52 1x1 caps Madopar HBS 2 uvece old patient

Overall Assessment

non PD

Subject performance similar to non PD population

Clinical context

In the clinical reference population, 0 individuals with a value less than 0.5 were subsequently diagnosed with PD. That is, 0.0% of the PD diagnoses in the study.

Additionally, 1 individuals with a value greater or equal to 0.5 were subsequently diagnosed as non PD. That is, 3.33% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 42, 'TN': 30, 'TP': 0, 'FP': 0}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 27, 'TN': 25, 'TP': 15, 'FP': 5}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 5, 'TN': 3, 'TP': 37, 'FP': 27}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 0, 'TN': 0, 'TP': 42, 'FP': 30}

Test Battery Details

Circle

numCircles 10
timePerCircleMean 3.812
timePerCircleCoV 0.181683
timePerCircleSlope -0.0481414
meanError 2.25919
tremorFreq 8.30078
tremorRelPower 29.0237
tremorGyroAmpMean 0.0572481
tremorGyroAmpSlope -0.0238831
tremorGyroAmpCoV 0.316455
tremorCoordAmpMean 0.157445
tremorCoordAmpSlope -0.00186493
tremorCoordAmpCoV 0.632964
tremorAccAmpMean 0.112506
tremorAccAmpSlope -0.0179566
tremorAccAmpCoV 0.296273
tremorPcRelVar 0.791859
tremorPcX 0.777903
tremorPcY 0.628385

Circle Segment 1

Duration 5.28 s, Accuracy Estimate 1.973 (lower is better)

Circle Segment 2

Duration 4.72 s, Accuracy Estimate 1.667 (lower is better)

Circle Segment 3

Duration 3.8 s, Accuracy Estimate 2.499 (lower is better)

Circle Segment 4

Duration 3.64 s, Accuracy Estimate 1.759 (lower is better)

Circle Segment 5

Duration 3.56 s, Accuracy Estimate 2.395 (lower is better)

Circle Segment 6

Duration 3.32 s, Accuracy Estimate 2.557 (lower is better)

Circle Segment 7

Duration 3.56 s, Accuracy Estimate 2.798 (lower is better)

Circle Segment 8

Duration 3.88 s, Accuracy Estimate 2.186 (lower is better)

Circle Segment 9

Duration 3.44 s, Accuracy Estimate 1.902 (lower is better)

Circle Segment 10

Duration 2.92 s, Accuracy Estimate 2.856 (lower is better)

Spiral

numSpirals 10
timePerSpiralMean 8.784
timePerSpiralCoV 0.198298
timePerSpiralSlope -0.0362643
meanError 2.74108
tremorFreq 7.03125
tremorRelPower 25.0921
tremorGyroAmpMean 0.0636527
tremorGyroAmpSlope -0.000335207
tremorGyroAmpCoV 0.367773
tremorCoordAmpMean 0.273921
tremorCoordAmpSlope 0.00063926
tremorCoordAmpCoV 1.24727
tremorAccAmpMean 0.0962099
tremorAccAmpSlope 0.00140228
tremorAccAmpCoV 0.345527
tremorPcRelVar 0.665274
tremorPcX 0.758878
tremorPcY 0.651232

Spiral Segment 1

Duration 12.32 s, Accuracy Estimate 1.833 (lower is better)

Spiral Segment 2

Duration 9.0 s, Accuracy Estimate 2.536 (lower is better)

Spiral Segment 3

Duration 10.6 s, Accuracy Estimate 2.363 (lower is better)

Spiral Segment 4

Duration 7.44 s, Accuracy Estimate 3.36 (lower is better)

Spiral Segment 5

Duration 8.92 s, Accuracy Estimate 2.495 (lower is better)

Spiral Segment 6

Duration 7.12 s, Accuracy Estimate 2.887 (lower is better)

Spiral Segment 7

Duration 7.28 s, Accuracy Estimate 2.562 (lower is better)

Spiral Segment 8

Duration 7.44 s, Accuracy Estimate 2.997 (lower is better)

Spiral Segment 9

Duration 10.04 s, Accuracy Estimate 3.365 (lower is better)

Spiral Segment 10

Duration 7.68 s, Accuracy Estimate 3.012 (lower is better)

Elel

eDurationMean 0.265333
eDurationStd 0.0607132
eDurationStdnorm 0.228819
eDurationMedian 0.2675
eDurationQuartdelta 0.06
eDurationQuartdeltanorm 0.224299
eDurationKurt 4.04833
eDurationTrenddiff 0.01
eDurationTrendratio 1.03774
eWidthMean 4.7112
eWidthStd 2.05172
eWidthStdnorm 0.435498
eWidthMedian 4.7385
eWidthQuartdelta 2.808
eWidthQuartdeltanorm 0.592593
eWidthKurt 2.49182
eWidthTrenddiff 0.702
eWidthTrendratio 1.16216
eHeightMean 11.4855
eHeightStd 4.10198
eHeightStdnorm 0.357144
eHeightMedian 11.4075
eHeightQuartdelta 5.85
eHeightQuartdeltanorm 0.512821
eHeightKurt 3.14138
eHeightTrenddiff -2.223
eHeightTrendratio 0.824074
eAspectMean 0.435985
eAspectStd 0.186716
eAspectStdnorm 0.428264
eAspectMedian 0.43773
eAspectQuartdelta 0.259233
eAspectQuartdeltanorm 0.59222
eAspectKurt 2.95112
eAspectTrenddiff 0.00824553
eAspectTrendratio 1.01907
eSlantMean -0.457556
eSlantStd 0.289857
eSlantStdnorm -0.63349
eSlantMedian -0.455013
eSlantQuartdelta 0.382344
eSlantQuartdeltanorm -0.840294
eSlantKurt 2.1516
eSlantTrenddiff -0.0328321
eRtopMean 0.557102
eRtopStd 0.295715
eRtopStdnorm 0.53081
eRtopMedian 0.56737
eRtopQuartdelta 0.483784
eRtopQuartdeltanorm 0.852678
eRtopKurt 2.31138
eRtopTrenddiff 0.170635
eRbotMean 1.87492
eRbotStd 0.949032
eRbotStdnorm 0.506173
eRbotMedian 1.85714
eRbotQuartdelta 1.12917
eRbotQuartdeltanorm 0.608013
eRbotKurt 6.22153
eRbotTrenddiff -0.339286
eRrightMean 0.761055
eRrightStd 0.224173
eRrightStdnorm 0.294555
eRrightMedian 0.801381
eRrightQuartdelta 0.3239
eRrightQuartdeltanorm 0.404177
eRrightKurt 4.15806
eRrightTrenddiff 0.133163
eRleftMean 0.614344
eRleftStd 0.147165
eRleftStdnorm 0.239548
eRleftMedian 0.607769
eRleftQuartdelta 0.184058
eRleftQuartdeltanorm 0.302842
eRleftKurt 2.3965
eRleftTrenddiff -0.023542
lDurationMean 0.3294
lDurationStd 0.0549303
lDurationStdnorm 0.166759
lDurationMedian 0.33
lDurationQuartdelta 0.05875
lDurationQuartdeltanorm 0.17803
lDurationKurt 6.44439
lDurationTrenddiff -0.02
lDurationTrendratio 0.940299
lWidthMean 4.66128
lWidthStd 1.78199
lWidthStdnorm 0.382296
lWidthMedian 4.68
lWidthQuartdelta 1.84275
lWidthQuartdeltanorm 0.39375
lWidthKurt 4.05466
lWidthTrenddiff -0.7605
lWidthTrendratio 0.848837
lHeightMean 28.4404
lHeightStd 5.62695
lHeightStdnorm 0.197851
lHeightMedian 27.846
lHeightQuartdelta 8.19
lHeightQuartdeltanorm 0.294118
lHeightKurt 2.75865
lHeightTrenddiff -4.3875
lHeightTrendratio 0.854369
lAspectMean 0.16821
lAspectStd 0.08131
lAspectStdnorm 0.483384
lAspectMedian 0.152542
lAspectQuartdelta 0.0494817
lAspectQuartdeltanorm 0.32438
lAspectKurt 8.90179
lAspectTrenddiff -0.0136932
lAspectTrendratio 0.917072
lSlantMean -0.257739
lSlantStd 0.121968
lSlantStdnorm -0.473224
lSlantMedian -0.234146
lSlantQuartdelta 0.18616
lSlantQuartdeltanorm -0.795058
lSlantKurt 2.34341
lSlantTrenddiff 0.0236082
lRtopMean 0.547497
lRtopStd 0.321981
lRtopStdnorm 0.588097
lRtopMedian 0.555556
lRtopQuartdelta 0.426924
lRtopQuartdeltanorm 0.768464
lRtopKurt 2.86387
lRtopTrenddiff 0.0235903
lRbotMean 2.59163
lRbotStd 1.64373
lRbotStdnorm 0.634246
lRbotMedian 2.16667
lRbotQuartdelta 1.19427
lRbotQuartdeltanorm 0.551202
lRbotKurt 9.7575
lRbotTrenddiff -0.0717189
lRrightMean 0.835278
lRrightStd 0.12435
lRrightStdnorm 0.148873
lRrightMedian 0.859296
lRrightQuartdelta 0.183776
lRrightQuartdeltanorm 0.213868
lRrightKurt 2.82542
lRrightTrenddiff -0.0262183
lRleftMean 0.658995
lRleftStd 0.19205
lRleftStdnorm 0.291428
lRleftMedian 0.683417
lRleftQuartdelta 0.225556
lRleftQuartdeltanorm 0.330042
lRleftKurt 2.30804
lRleftTrenddiff -0.147986

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

FITTS Short Modified

meanTouchScore 0.844742
sumTouchScores 24.4975
meanMovementTime 0.653036
numTouches 29
undershootPercentage 0
overshootPercentage 27.5862

FITTS Long Modified

meanTouchScore 0.790561
sumTouchScores 18.9735
meanMovementTime 0.798478
numTouches 24
undershootPercentage 0
overshootPercentage 37.5

ZigZag

numZigzags 5
timePerZigzagMean 9.288
timePerZigzagCoV 0.0951561
timePerZigzagSlope -0.0443583
meanError 3.45161
tremorFreq 6.34766
tremorRelPower 21.5392
tremorGyroAmpMean 0.108509
tremorGyroAmpSlope 0.001432
tremorGyroAmpCoV 0.289651
tremorCoordAmpMean 0.204881
tremorCoordAmpSlope 0.0133527
tremorCoordAmpCoV 0.516136
tremorAccAmpMean 0.137481
tremorAccAmpSlope 0.0042146
tremorAccAmpCoV 0.206667
tremorPcRelVar 0.741784
tremorPcX 0.240686
tremorPcY -0.970603

ZigZag Segment 1

Duration 10.48 s, Accuracy Estimate 3.461 (lower is better)

ZigZag Segment 2

Duration 9.0 s, Accuracy Estimate 3.217 (lower is better)

ZigZag Segment 3

Duration 9.2 s, Accuracy Estimate 3.406 (lower is better)

ZigZag Segment 4

Duration 9.68 s, Accuracy Estimate 3.508 (lower is better)

ZigZag Segment 5

Duration 8.08 s, Accuracy Estimate 3.666 (lower is better)

ZigZag Offset

numZigzags 5
timePerZigzagMean 6.848
timePerZigzagCoV 0.0508211
timePerZigzagSlope -0.0303738
zigzagHeightMean 61.4474
zigzagHeightCoV 0.0923939
zigzagHeightSlope 0.0574482
meanError 0.0484814
tremorFreq 5.95703
tremorRelPower 42.093
tremorGyroAmpMean 0.166619
tremorGyroAmpSlope 0.0313452
tremorGyroAmpCoV 0.39597
tremorCoordAmpMean 0.363578
tremorCoordAmpSlope 0.0063187
tremorCoordAmpCoV 0.702631
tremorAccAmpMean 0.194531
tremorAccAmpSlope 0.0175224
tremorAccAmpCoV 0.349001
tremorPcRelVar 0.771161
tremorPcX -0.295968
tremorPcY -0.955198

ZigZag Offset Segment 1

Duration 7.4 s, Accuracy Estimate 0.038 (lower is better)

ZigZag Offset Segment 2

Duration 6.88 s, Accuracy Estimate 0.065 (lower is better)

ZigZag Offset Segment 3

Duration 6.84 s, Accuracy Estimate 0.039 (lower is better)

ZigZag Offset Segment 4

Duration 6.64 s, Accuracy Estimate 0.056 (lower is better)

ZigZag Offset Segment 5

Duration 6.48 s, Accuracy Estimate 0.044 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.51}
RanFor {‘RanFor_class’: ‘NOT PD’, ‘RanFor_score’: 0.5}
BM_May22 {‘BM_May22_class’: ‘PD’, ‘BM_May22_score’: 0.7358713365250249}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.9393154245745396}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘nonPD’, ‘BM_PD_Sep22_score’: 0.47878504810881045}